Guest,您好!  [ 退出系统 ]
 
 
本系统提供的服务仅限于教学、科研及个人学习的目的,请合理使用!
首页 - 文献检索 - 文献细览(期刊文献)
 
Genes & Development
0890-9369 Vol.24, 7(2010)
p.-
MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development
Auinash Kalsotra , Kun Wang , Pei-Feng Li , and Thomas A. Cooper
 Abstract:Alternative splicing transitions have been identified recently as a conserved component of vertebrate heart remodeling during postnatal development. Here we report that the targeted deletion of Dicer , specifically in adult mouse myocardium, reveals the role of microRNAs (miRNAs) in regulating networks of postnatal splicing transitions and in maintaining adult splicing programs. We demonstrate a direct role for miR-23a/b in the dramatic postnatal down-regulation of CUGBP and ETR-3-like factor (CELF) proteins that regulate nearly half of developmentally regulated splicing transitions in the heart. These findings define a hierarchy in which rapid postnatal up-regulation of specific miRNAs controls expression of alternative splicing regulators and the subsequent splicing transitions of their downstream targets.
下载题录  |  原文收割  |  参考译文  |  推荐[0]  |  分享到:
新浪微博 腾讯微博  

关于我们   |   联系我们   |   意见或建议   |   检索技巧   |   在线客服
古扬科技   渝公网备:500199095-00008   渝ICP备:10200524号
建议使用IE6以上版本,1024*768分辨率浏览本页面