Guest,您好!  [ 退出系统 ]
 
 
本系统提供的服务仅限于教学、科研及个人学习的目的,请合理使用!
首页 - 文献检索 - 文献细览(期刊文献)
 
Microbiology and Molecular Biology Reviews
1092-2172 Vol.73, 02(2009)
p.-
At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci
Somerville, Greg A.; Proctor, Richard A.
 Abstract:Summary: Bacteria live in environments that are subject to rapid changes in the availability of the nutrients that are necessary to provide energy and biosynthetic intermediates for the synthesis of macromolecules. Consequently, bacterial survival depends on the ability of bacteria to regulate the expression of genes coding for enzymes required for growth in the altered environment. In pathogenic bacteria, adaptation to an altered environment often includes activating the transcription of virulence genes; hence, many virulence genes are regulated by environmental and nutritional signals. Consistent with this observation, the regulation of most, if not all, virulence determinants in staphylococci is mediated by environmental and nutritional signals. Some of these external signals can be directly transduced into a regulatory response by two-component regulators such as SrrAB; however, other external signals require transduction into intracellular signals. Many of the external environmental and nutritional signals that regulate virulence determinant expression can also alter bacterial metabolic status (e.g., iron limitation). Altering the metabolic status results in the transduction of external signals into intracellular metabolic signals that can be "sensed" by regulatory proteins (e.g., CodY, Rex, and GlnR). This review uses information derived primarily using Bacillus subtilis and Escherichia coli to articulate how gram-positive pathogens, with emphasis on Staphylococcus aureus and Staphylococcus epidermidis, regulate virulence determinant expression in response to a changing environment.
下载题录  |  原文收割  |  参考译文  |  推荐[0]  |  分享到:
新浪微博 腾讯微博  

关于我们   |   联系我们   |   意见或建议   |   检索技巧   |   在线客服
古扬科技   渝公网备:500199095-00008   渝ICP备:10200524号
建议使用IE6以上版本,1024*768分辨率浏览本页面